Abstract: Most shale gas exploration blocks in South China are new exploration areas, only a small number of 2D seismic and geological drilling are deployed there, and the data quality is generally poor.Therefore, it is difficult to carry out systematic research on shale gas reservoir prediction like mature exploration areas.How to fully use the only data is the key to predicting the shale gas reservoir in the new exploration area.The post stack constrained sparse pulse inversion method independent of the initial model and a variety of frequency attribute analysis techniques were used to predict favorable shale gas reservoir.Seismic inversion can make full use of a variety of information parameters to participate in reservoir prediction, and attribute analysis can identify reservoirs from multiple angles.In addition, comprehensive application of multiple information and superposition analysis can improve the accuracy and effectiveness of reservoir prediction, which provides a new idea for shale gas exploration in new exploration area.The technology was applied to a block in South China, and the favorable target of shale gas was delineated.The two horizontal wells deployed in the area obtained high-yield industrial gas flow.