Abstract: Located in northwestern Hunan Province, the Shizishan Pb-Zn deposit is stratabound and contains huge amounts of Pb and Zn resources. The ores are hosted in the Lower Cambrian Qingxudong Formation, a sequence of algal and clastic limestones, ranging from 22.6m to 237m in thickness. The ore-hosting rocks are divided into the upper, middle and lower unit. The authors discussed the major factors controlling the mineralization on the basis of analysis of the distribution of ore-bearing rocks and ore enrichment.