Abstract: In this paper, the integrated geological database was established based on overall collection and analysis of geological information using the Minexplorer software in the Limei Pb-Zn deposit of northwestern Hunan. A 3D deposit model was built mainly on 3D borehole data of the study area. Especially, the ore body model and stratigraphic model were taken as examples to introduce the general way for 3D geological modeling at the deposit scale. Reserve estimation was conducted based on the orebody model by using three methods, i.e., geological ore block method, geological section method, and geological statistics method. The results were compared with the results submitted in geological prospecting report of the deposit. It is proved that 3D modeling and reserve estimation using the Minexplorer software have several advantages such as convenience, better visualization and accuracy.