Abstract: Abstract：The Nanling region is an important tungsten-tin metallogenic province in China, where tungsten and tin mineralizations have close relations with the Yanshanian granite in the region. In the study of the Nanling granite, the authors found that higher values of εNd and lower values of T2DM indicate contamination with more mantle material. More tin mineralization occurs in Hangzhou-Zhuaguangshan-Huashan belt, where the granite contains more mantle contaminants; whereas tin mineralization is of infrequent occurrence where mantle contaminants are less. This paper summarizes the isotope, trace element and REE data of the Guposhan, Qitianling, Qianlishan and Dajishan intrusions and, on that basis, compares the relative contents of mantle contaminants, magmatic evolution and characteristics of the exsolution fluids in the source rocks of the four intrusions. According to this comparison, combined with the differences in mineralization types between the four intrusions, this paper concludes that the differences in amount of mantle contaminants can determine the differences of tungsten and tin mineralizations by influencing the granite magmatic evolution related to mineralization.