Abstract: The establishment of prospecting prediction theory and method of metallogenic geological body provides theoretical and methodological guidance for prospecting in the exploration areas. This theory was widely used in the prospecting prediction and mineral exploration of ore-concentrated areas and the deep and/or peripheral of old mines. In practice, excellent prospecting effects have been achieved in 83 ore concentration areas and 168 mines, such as Yindongpo Au-Ag ore-concentrated area in Henan, Zaozigou Au deposit in Gansu, Lala Cu ore-concentrated area in Sichuan, and so on. The core of this theory is to construct a "trinity" prospecting prediction geological model (namely, metallogenic geological body, metallogenic structure and metallogenic structural plane, and metallogenic characteristics). The application main points of this theory are as follows. Firstly, carry out pre-comprehensive research and typical deposit research, and then put forward to the main type of deposit and prospecting ideas. Secondly, construct prospecting prediction geological model to determine metallogenic center. It mainly includes studying metallogenic geological body, metallogenic structure and metallogenic structural plane, and metallogenic characteristics, with aim to determine prospecting direction, the location of ore-body, and provide ore-body occurrence basis, respectively. Thirdly, integrated application of geophysical and geochemical exploration method to identify the location of potential validation engineering. Finally, carry out prospecting engineering verification in the hope of achieving prospecting breakthrough. The core purpose of this paper is to provide ideas and demonstration for the prospecting prediction work, and to provide support services for the new round of prospecting breakthrough strategic action.