Abstract: Based on the a 1:10000 tectonic altered lithofacies mapping and 1:2000 measured section, this paper takes the Sandaozhuang Mo (Wu) deposit as the study area, and comprehensively observed the typical altered minerals and mineral assemblage features of the tectonic altered lithofacies zones, researches the typical character of mineral assemblages and content change. Combined with the analyses of field work and microscopic observation, we presented two alteration types of the Sandaozhuang Mo (Wu) deposit, i.e. thermo-contact and hydrothermal metasomatism. Thermo-contact metasomatism included quartzite zone, biotite-felsic hornfelsic zone, diopside-felsic hornfelsic zone, and hydrothermal metasomatism included skarn zone and calc-silicate skarnization-hornfelsic zone. This paper summarized the characteristics of structural altered lithofacies belts from the conduct of macroeconomic and microeconomic analysis, and then compiled structural altered lithofacies zoning map of the wall rock in Sandaozhuang Mo (Wu) deposit. This research provides new thinking and achievement on the regularity of ore formation of porphyre-skarn Mo (Wu) deposit, which shows important theoretical significance and application value between petrography and structure.