Abstract: Reservoir sensitivity is the degree of sensitivity to various factors that cause damage to the reservoir. The main purpose of reservoir susceptibility analysis is to study the damage degree of various sensitive factors to reservoirs and to propose preventive measures to improve the final recovery rate of crude oil. In order to study the damage to the reservoirs in the Permian reservoirs in the Babei depression of the Yingen-Ejinaqi basin, the authors carried out a large number of laboratory experiments on the core of the reservoir. The reservoir sensitivity test was used to evaluate the reservoir sensitivity. The standard was evaluated for the sensitivity of the area. The results show that the reservoirs of the Permian buried Khan Formation are intermediately strong, sensitive, weakly alkaline, moderate to strong, and slightly weak and medium weak. In the future exploration and development, the protection of oil and gas as well as the increase in the choice of measures can be used to respond to the corresponding measures.