Abstract: Located in the northeast of the Huize lead-zinc deposit, the Gaojiajing exploration area is a favorable ore-forming area located on the northeast side of the Kuangshanchang faults. On the basis of the 1:5000 structure geological mapping, the authors studied and summarized the structural styles based on an analysis of the mechanical properties of typical structural surfaces, and consider that the Gaojiajing exploration area is controlled by the thrust-fold structures, NE-trending left-slip compression torsion interlayer faults and NW-trending transtensional faults and is the favorable place in search for ore bodies. In late Indosinian period, Permian-Sinian strata were reversed and the NE-trending drag fold was formed under the action of the NE-striking stress. These factors constituted the tectonic framework of the Gaojiajing exploration area and provided passage and storing space for the flowing metallogenic fluids. The authors extracted alteration information by calculating chemical index of alteration, and delineated three strongly altered places. The authors extracted the combined anomalies of Pb-Zn-Cd-Ag and As-Sb-Hg by using factor analysis method, and delineated four anomaly areas. The abnormal distribution which reflects the "multi-layer" mineral exploration potential was found in Sinian, Devonian and Carboniferous strata. The ore-prospecting direction and the prospecting target are proposed by synthesizing the exploration technology of ore-control structure, mineralized alteration and tectono-geochemistry.