Abstract: The comprehensive research on the metallogenic material sources of the main non-ferrous metal deposits in northeastern Hu'nan Province has been very insufficient. Focusing on the Taolin lead-zinc deposit, Lishan lead-zinc deposit and Jingchong Cobalt-copper polymetallic deposit, the authors analyzed their S and Pb isotope geological characteristics of the single mineral of sulfide ore in their main metallogenic period, explored comprehensively the law of ore-forming material sources about the nonferrous metal ore deposits in northeastern Hu'nan Province, combined with research status of other deposits such as the Qibaoshan copper polymetallic deposit. The S isotope characteristics show that the metallogenic material of four deposits came from the deep magmatic sulfur source on the whole. The Qibaoshan ore deposit is a typical magmatic sulfur source, whereas the Taolin, Lishan and Jingchong deposits are all mixed with a small amount of formation sulfur. Moreover, the deposit with higher percentage of formation sulfur source is Taolin deposit. The Pb isotope characteristics show that the metallogenic material source of the four deposits is given priority to the upper crust, but is mixed with minor mantle source material on the whole. The higher mixing proportion of mantle source material came from Qibaoshan and Jingchong.