Abstract: The Early Cretaceous granites in the Menba area are located in the eastern segment of the Gangdise belt, being an important part for the study of Gangdise evolution. With biotite granite and two mica granite in Menba area as the object of study, the author analyzed the geochemical characteristics and tectonic setting of the Early Cretaceous granites in this area by using the method of rock geochemistry and zircon U-Pb chronology. In this paper, the zircon samples for the test and analysis have obvious oscillation ring band, belonging to zircon of magma origin, and the LA-ICP-MS zircon ²⁰⁶Pb/²³⁸U age is 139.4~140.6Ma, suggesting Early Cretaceous. The geochemical characteristics of rocks indicate that the Early Cretaceous granites in Menba area are rich in silicon, high in alkali, and poor in FeO, MgO, CaO, implying strong aluminum high differentiation granite and high potassium calcium alkaline series, with the trend of homologous magma evolution; the model of rare-earth element allocation is the right type with Rb, Ba, Th, Nb, Ce enrichment and Hf, Zr, Sm, Y, Yb depletion. The granite in Menba area was formed in the land-land collision orogenic environment, the tectonic background was gradual transition from "the same collision" to the tectonic environment after "orogenic period", which had the extensional tectonic characteristics of "post collision", and was the magma response to the soft flow ring upwelling or the basalt bottom invasion.