Abstract: Two samples were collected near the Zhagutian uranium ore deposit and Zhangjia uranium ore deposit respectively to carry out LA-ICP-MS zircon U-Pb isotopic dating. The analytical result demonstrates that the formation age of the host rock in the Zhagutian uranium ore district is 218.0±1.4Ma, whereas the formation age of the host rock in the Zhangjia uranium ore district is 226.8±5.7Ma. Furthermore, the Zhangjia granite is characterized by high SiO₂ (74.35%~76.29%), Al₂O₃ (12.54%~14.03%) and (Na₂O+K₂O) (6.95%~9.17%), but low MgO (0.34%~0.45%), CaO (0.68%~1.03%) and TiO₂ (0.106%~0.18%), so it belongs to high-K calc-alkaline series granite. The Zhangjia granite is rich in Rb, and poor in Ba, Sr with high Rb/Sr ratio, so it belongs to low Ba-Sr granite series. The granite is rich in LREEs with negative Eu anomalies. Meanwhile, The granite is rich in U (21.5×10^-6 on average)with low Th/U ratio (1.63 on average), so it is very favourable for uranium mineralization. The granite has high (⁸⁷Sr/⁸⁶Sr)_i (~0.7247), low ε_Nd (t) (-13.95 on average) and its two-stage Nd isotopic model ages are (2.07~2.19Ga). The Zhangjia granite belongs to strongly peraluminous S-type granite. It probably originated from partial melting of Proterozoic sedimentary metamorphic rocks.