Abstract: Latin America is one of the regions that have richest mineral resources in the world. In this paper, the authors have summarized the metallogenic geological setting of this region, divided the metallogenic zones, and studied the metallogenic series so as to guide the further planning and development. In this paper, the tectonic contours of the earth were divided into three tectonic domains, with a discussion on the secondary tectonic zones. As for the division of metallogenic belts, the authors classified the zone into primary metallogenic domain and secondary metallogenic province according to the five-stage metallogenic zone scheme. For the metallogenic units of level 3 and under level 3, the authors made a brief comparison with previous results. In terms of metallogenic series, the authors took the tectonic evolution as the guidance and the mineralization and deposit types as the indicators, collaborated the deposits that have inner connection into one series, and then divided them into sub-class metallogenic series and metallogenic assemblages.