Abstract: Pearl River Delta is a complex anastomosed delta system, and a number of debatable views concerning the environmental evolution during Quaternary period have existed since the 1970s-1980s. For a better understanding of the process, multidisciplinary approaches to the Core QZK6, drilled recently in the west bank of Pearl River estuary, have been carried out for exploring the environmental changes superimposed upon the depositional characteristics, including depositional structure and texture, grain size and organic carbon isotope analyses, AMS ¹⁴C and OSL (optically stimulated luminescence) dating. It is indicated that the terrestrial sedimentation of weathered layers and fluvial deposits at the depth of 39.40~27.38m formed in the Late Pleistocene, the retrograde delta sedimentation of delta plain, delta front and prodelta at the depth of 27.38~5.30m developed during the 10.982~2.087ka cal BP, and the prograding delta sedimentation of estuary to delta front at the depth of 5.30~2.00m deposited during the 2.087~0.203ka cal BP, were responses to the sedimentary environments with a low stand sea level during the last glacial period, a growing sea level during the Early to Middle Holocene, and a falling sea level during the Late Holocene respectively.