Abstract: It is generally thought that both tectonic events and magmatic activities during the Indosinian period were intense in south-eastern China. In contrast, the Indosinian magmatic activities in southern Anhui area were generally not considered to be existent, be-cause there was not any previous reported Indosinian intrusive rock in this area. In this paper, the authors obtained LA-ICP-MS zir-con U-Pb weighted average age of 245.2±2.4Ma for the quartz porphyry dyke from the side of x046 highway, about 500m north of Dongkengkou Village, Huizhou District, Huangshan City, southern Anhui Province, which implys that the Dongkengkou quartz por-phyry (DQP) was formed during Indosinian period rather than in Yanshanian period. The bulk-rock chemical data indicate that the DQP is enriched with LILE, LREE and depleted in high field-strength elements Ba, Sr, P, Ti, and possesses high 10000×Ga/Al ra-tios and high Zr, Nb, Ce and Y values. Petrologically, the DQP has hypidiomorphic quartz and plagioclase, exhibiting A-type gran-ite characteristics. The confirmation of the Indosinian A-type granite from southern Anhui area provides new scientific evidence for understanding the regional tectono-magmatism history, and finally supplies extra evidence for remodeling the tectonic and geody-namic evolution of southeast China.