Abstract: The matrix effect is a problem of much concern in U-Pb isotopic dating by in situ LA-ICP-MS，and its influence on the accuracy of the dating results should not be ignored. The authors intend to study the influences and correction methods of matrix effects on U-Pb isotopic dating by in-situ LA-ICP-MS for such minerals as baddeleyite, rutile, cassiterite, columbite, uraninite, pitchblende and other oxide-type U-bearing minerals. This paper briefly describes the advantages and limitations of these correction methods in the hope of finding some regularity and similarity and solving difficult points in rare minerals standards preparation. In the accurate U-Pb isotopic dating by in situ LA-ICP-MS, the correction methods are of important scientific significance for further comprehensive understanding of the relevant geological generation and evolution history of the deposit, establishment of more accurate structural framework and creation of new petrogenic and metallogenic model.