Abstract: The Herlen-Manzhouli metallogenic belt, which possesses abundant mineral resources, is located along the border area of northeastern China and eastern Mongolia. The lead-zinc ore concentration area ranging from N 48°, E 114° to N 50°, E 117° in the China-Mongolia border area has Chaganbulagen, Halashenggelataolegai lead-zinc deposits and Jiawula silver-lead-zinc deposit in China and Tsav, Ullan lead-zinc deposits in Mongolia. Based on field geological work and research on these deposits, the authors systematically investigated lithgeochemical characteristics and obtained zircon U-Pb ages by means of LA-ICP-MS. According to the results obtained, volcanic rocks-subvolcanic rocks-intrusive rocks related to mineralization mostly belong to sub-alkaline series, with similar distribution models of rare elements; the Ullan lead-zinc deposit has obvious negative anomalies of δEu, whereas other deposits have relatively weak negative anomalies of δEu; J3-K1 should be the ore-forming epoch, as shown by zircon dating data; lead-zinc deposits in the belt should be defined as subvolcanic hydrothermal lead-zinc deposits formed in an extensional setting in J3-K1. Making use of these results, the authors made a comparative study and analysis of the above deposits in the same metallogenic belt so as to reveal the metallogenic characteristics and regularity of the area. The results achieved by the authors provide a theoretical basis for lead-zinc ore prospecting in this area.