Abstract: The analytical method matching scheme of 19 elements in geochemical samples in Karaqi area of Southwest Tianshan Mountains was optimized by changing the sample dissolving method, improving the analytical method and considering the characteristics of the sample. The quality management system comprising man, machine, material, method, measurement and surroundings was established and improved. The laboratory information management system consisting of seven modules (LIMS) responsible for the quality management information and standardization was also developed and constructed. The scientific and perfect 1∶50000 regional geological and mineral survey sample quality monitoring system was constructed by internal and external controlling methods for accuracy, precision, repeatability test, abnormal point and external monitoring. By adopting various means, establishing foundation of information courses and utilizing advanced monitoring system graphic display, the authors have supplied accurate geological-geochemical information for geochemical prospecting and basic research in Karaqi area of Southwest Tianshan Mountains.