Abstract: Regional geochemical quantitative prognosis is a part of the project of national important mineral resources evaluation. For the purpose of improving the reliability of prediction results, the building of scientific and reasonable geological and geochemical prospecting model is very crucial, and is also regarded as the "standardized sample" for geochemical prospecting areas and resources calculation. Firstly, through a historical retrospect of the geochemical prospecting model in China, this paper has discussed basic strategy, theoretical foundation, and major contents of the prospecting model. Secondly, based on the above idea and many latest literatures, this paper presents a case of geological and geochemical prospecting model. The prospecting model is for the Jiama trinity deposit consisting of three types of ore-bodies i.e., skarn-type, hornfels-type, and porphyry-type, in the Gangdise metallogenic belt. The model comprises six aspects, which are regional geological characteristics, geological characteristics of ores, geochemical characteristics of ores, geochemical anomaly characteristics, summary of geological-geochemical characteristics, and dominant ore-control factors.