Abstract: Through comprehensive analysis of tectonics, focal mechanism, foreshocks, aftershocks and seismic investigation records, the seismic focal physical process was tentatively summarized. It was pointed out that, 2009 Yao′an Ms 6.0 earthquake which was given out by the smash-like fracture conducted by stress concentration along the north edge of year 2000 aftershock layer with about 10km deep was the extension of 2000 Yao′an Ms 6.5 earthquake process. By timely field investigation and literature survey, it was recognized that the seismic damage was more server than that of Yao′an Ms 6.5 earthquake in 2000. The reason might mainly be shallow focus and horizontal vibration, and the majority earthquake disasters were ground deformation and building destruction, which were bound up with geologic environment. It was suggested that the reconstruction in the epicenter region of Ms 6.0 earthquake and its aftershocks should be prohibited, and the evaluation on houses geo-hazard risk in rural areas should be reinforced. The foundation investigation and treatment in construction should be intensified. The quality of construction should be improved. Anti-quake construction design should be strengthened, and attention to the search for and treatment of hidden disaster in the construction areas and buildings affected by the earthquake should be paid.