Abstract: According to the technical requirements of national mineral resources potential evaluation, this article, taking the bauxite resource prediction in Guizhou Province as the example, this paper focuses on the prediction units division of the geological-unit and grid-unit method, the selection of essential factors for prediction, assigning value to essential factors as well as discussion of the influence of geological mapping scale, the characteristics of mineral deposit, geophysical and geochemical remote sensing information on mineral resource prediction, with the introduction of mineralizing types and its characteristics, prediction methods of sedimentary bauxite resource in China. This grid-unit method has considered the most essential prediction factors, and its accuracy has reaches to each single orebody or deposit.