Abstract: Being one of the most important metallogenic regions of western China, eastern Tianshan area has wonderful conditions for Pb-Zn deposits formation. Pb-Zn deposits are located in Tarim ancient land block mainly and some of them are in Aqishan Early Carboniferous rift zone secondly. There are four deposit types: Strata-bound type, scarn type, hydrothermal type and volcanic massive sulfide type. We summarize the predictive elements based on study of typical deposits. Using Evidence Weight method, we delineated 68 forecasting areas. Geological features of this area suggest good prospecting potential.