Abstract: In this paper, combining with the discovery of Lianmeng silver-gold mineralized spot at southeast of Chengmenshan copper deposit, we discussed the importance of carrying out refined geochemical prospecting. That is to follow the criteria of "on the mineral prospecting" and spatial-temporal superposition mineralization of the copper-polymetallic ore deposits, on the basis of geology, guided by modern geochemical ore-forming theory and supported by geochemical exploration of new technologies, new methods and high-precision test, we carried out a new round of geochemical prospecting method research in the depth and periphery of the old mining areas.