Abstract: The distribution, formation and concentration characteristics of high-fluorine groundwater were made clear through sampling investigation of groundwater. The origin of high-fluorine groundwater was analyzed in the meteorological, geological, geomorphological, hydrogeological and hydrogeochemical contexts. The results show that the distribution, formation and concentration of high-fluorine groundwater were controlled by the geological, geomorphological, hydrogeological and climatic conditions and resulted from long-continued integrated effects of the aforesaid various factors. On that basis, the preliminary treatment measures were proposed as reference for solving the problem of safe drinking water in the Dali County.