Abstract: The important characteristics of the geological evolution in the core part of the Central Asian metallogenic domain are its multi-stage growth and evolution of Paleozoic crest, polycyclic mobilization-remobilizadon materials and long-contin- ued and cyclic metallogenic environment. These characteristics determined multiple transport and concentration of ore-forming materials. This metallogenic domain comprises several metallogenic provinces and its core part is composed of the Altay, circum-Balkhash-Junggar and Central-South Tiamhan metallogenic provinces. A metallogenic province includes several metallo- genic belts, each metallogenic belt is made up of several ore deposit concentration areas, and each ore deposit concentration area contains at least one large or superlarge deposit. After the closing of the Paleo-Asian Ocean, the Indosinian metallogenesis developed in the core of the Central Asian metallogenic domain was mainly controlled by ductile shear zones and smaU-scale crest-derived magmadsm. The key scientific problems in the core of this metallogenic domain include the constraint of the flnid-magmatic evolution on mineralization in the Paleo-South Tianshan subducdon zone, environment for the formation of the gigantic porphyry copper belt, reconstruction of the Late Paleozoic tectonic framework, characteristics of the gigandc ductile shear zone and its controlling mechanism for gold mineralization.