Abstract: Based on an analysis of the data of regional geological and geophysical and geochemical anomalies, the paper analyzes and discusses the structural characteristics and ore-forming element distribution in different strata and rock suites in the eastern segment of the Altyn Tagh Mountains, with the focus on the distribution characteristics of regional geochemical anomalies in the area. In addition, the paper analyzes and infers the geological factors that formed anomaly concentration zones of Cu, Pb, Zn, Au and Ag and discusses geochemical anomalies and regional metaUogenesis. The authors think that the eastern segment of the Altyn Tagh Mountains has a relatively large ore potential and preliminarily discusses the direction for mineral search.