Abstract: The Luffilian Arc is an extremely important Cu-Co mineralization belt in world, and the Cu-Au-Co-Ni-U mineralization subzone in the Northwestern province of Zambia is an important component of Luffilian Arc.However, its basic geological work is fewer and is lack of systematic research on mineralization mechanisms.Based on the research on the geochemical characteristics of river sediments, soil geochemical characteristics, geophysical characteristics and typical Cu-Co deposits, this paper summarizes the metallogenic geological evolution and metallogenic of Northwestern province of Zambia, and proposes the regional prospecting direction, to achieving in more Cu-Co deposits in this area.The Dome area of Luffilian Arc is mainly distributed in Northwestern province of Zambia, producing copper, gold, cobalt, uranium, nickel and other important metal minerals.The ore bearing strata are carbonaceous shale and phyllite of the Roan Group, and the mineralization type is mainly metamorphic hydrothermal vein type.The ore deposit is formed because of the activation of ore-forming materials and the migration of ore bearing hydrothermal fluid along the fault under the Pan African NW-SE compression, and the precipitation and enrichment of ore-forming due to the change of physical and chemical conditions; The Shivuma IOCG type Cu-Au-Co deposit in the southern margin of the syncline belt occurs in the NE trending copper bearing carbonatite.The deposit is formed because the initial mantle rises along the deep fault to the shallow crust.Due to the temperature and pressure drop, the initial magma continues to evolve and mineralize eventually.By researching the genesis and metallogenic model of the typical deposits in northwest Zambia, it is proposed that the future prospecting direction should find the Cu-Au-Co deposits controlled by both structure and strata in the nappe belt around the basement of the Dome area, and utilizing aeromagnetic anomalies and geochemical anomalies in the tectono magmatic belt in the syncline zone to find IOCG type Cu-Au-Co-Ag-Fe deposits at the intersection of NW trending deep faults and NE trending faults.