Abstract: Based on the long series data of four national meteorological stations during 1960-2017 in the periphery Badain Jaran desert and the short series data of 10 meteorological stations during 2016-2018 in the hinterland of Badain Jaran desert, the unitary linear regression model and Mann-Kendall test were used to systematically analyze the spatio-temporal variation characteristics of temperature and precipitation in the periphery and hinterland of Badain Jaran Desert.Combined with the research results of the project team and predecessors on lake dynamics, the change characteristics are analyzed, and the response relationship between lake changes and climate factors is preliminarily discussed in Badain Jaran Desert.The results showed that the average annual temperature shows a rising trend, and the heating rate increased from south to north, among which the Alxa Right Banner increased significantly at a rate of 0.74℃/10a.The variation trend of precipitation is not significant in the periphery of Badain Jaran Desert; in generalthe, the climate in the southeast edge of the desert has been warm and humid, while that in the northwest edge has been warm and dry in the past 50 years.The annual precipitation and temperature showed sudden changes in the 1970s and 1980s.The sudden changes in precipitation were not obvious, but the sudden changes in air temperature were significant, since then, the climate has become warmer and drier in the periphery Badain Jaran Desert; the characteristics of the monthly climate are basically the same, both of which have the characteristics of simultaneous water and heat, high temperature and rainy in summer, and cold and dry in winter in the periphery and hinterland of Badain Jaran Desert.However, the rainy season is shorter and earlier in the hinterland of Badain Jaran Desert than that in the periphery of Badain Jaran Desert.The lakes have been shrinking in different degrees for many years in the desert area, and the accelerated shrinking of lakes is controlled by the sudden change of local climate warming and drying; the annual water level, water volume peak value of the lake and precipitation peak value are inconsistent, indicating that the precipitation change is not the main control factor of the lake change.