Abstract: The Au-Cu-Ag polymetallic deposit has favorable ore-forming conditions and great prospecting potential in the Zhashui-Shanyang ore concentration area. The area can be divided into five sub-series of Au-Cu-Ag-Fe-Pb-Zn-Sb minerogenetic sub-series related to tectono-magmatic hydrothermal activity in the Late Jurassic-Early Cretaceous, Mo-W minerogenetic subseries related to intermediate-acid magmatic activity in the Late Triassic and Cu-Fe-Pb-Zn-Ag minerogenetic subseries of carbonate-host related to hot water jet deposition in the Devonian period. The prospecting criteria of the Au-Cu-Ag polymetallic deposit are summarized. The comprehensive prospecting models of Xiajiadian Au deposit, Chigou Cu-Mo deposit, Yindongzi Ag-Pb polymetallic deposit, Longtougou Au deposit and Wangjiaping Au deposit are established respectively. Through the concrete application of comprehensive prospecting method and prospecting model in the area, the prospecting prediction has been made, and better prospecting progress has been achieved. The amount of gold, silver and lead resources are 42 tons, 450 tons and 400 000 tons respectively in the two ore-prospecting target areas of Xiajiadian cond Fenggou-Xitianjiagou. In this paper, the author puts forward a combination of different prospecting methods in three stages: pre-prospecting and selecting area, general survey and evaluation, and detailed exploration, which provides a reference model and method basis for further prospecting in the area.