Abstract: Extensional structures developed in the Late Mesozoic in eastern China, which induced intense magmatic activity and large-scale metallogenic events.This paper will extend structure of the Late Mesozoic magmatic core complex and edge exposed detachment fault as the main logo, the multiphase magmatic intrusion formed metamorphic core complex and extensional dome are classified as the structural category of Late Mesozoic magmatic core complex uplift-detachment belts.The former mainly forms deep-sourced gold-polymetallic deposits, while the latter mainly forms shallow-sources non-ferrous metal deposits.The former is mainly distributed in the area of ancient metamorphic rocks, while the latter mainly occurred in the area of Paleozoic sedimentary-volcanic rocks.The inducement of magmatic uptrusion is mainly related to the subduction-reentry mechanism of the Pacific plate in Late Mesozoic.Combining with geophysical data, the deep controlling factors of magmatic core complex are discussed.Based on the post-magmatic hydrothermal metallogenic model of magmatic core complex uplift-detachment zone, the distribution, metallogenic conditions and prospecting criteria of magmatic hydrothermal deposits of precious and non-ferrous metals are summarized.A new direction of mesoscale ore field prospecting is proposed, and favorable concealed prospect areas are predicted in southern Liaonan and northern Anhui.