Abstract: 　　The Gutaishan gold-antimony deposit in central Hunan is located in the southwestern segment of the Xuefeng orogenic belt and is a typical medium-low temperature hydrothermal deposit controlled by faults. Relying on regional geology, deposit geochemistry, and deep exploration data, this paper systematically analyzes its metallogenic regularity and the prospecting potential in deep and peripheral parts. The research shows that the formation and distribution of the deposit are controlled by multiple factors: The NE-trending deep and large ore-conducting faults (represented by F1) provide migration channels for ore-forming fluids. The N-S and NW-trending secondary faults act as ore-hosting structures. The NW-trending faults dominate the development of “Au-Sb symbiotic” ore veins, and the N-S trending faults control the gold ore veins. The differentiation of ore veins originates from the staged transformation of the Indosinian tectonic stress field (from NW-SE compression to NWW-SEE compression) and the coordinated evolution of the properties of ore-forming fluids (the relatively high oxygen fugacity environment in the early stage is conducive to Au migration while Sb is restricted; in the late stage, the decrease in oxygen fugacity and the increase in sulfur fugacity promote the joint igratin and enrichment of Au and Sb). The sources of ore-forming materials are multi-source, with deep metamorphic fluids and magmatic fluids as the main body,
　　and the strata also contribute part of the materials. Deep drilling verifies the vertical zoning regularity of the deposit: From near-surface to shallow to middle-deep parts, the ore-forming elements show a trend of Sb→Sb-Au→Au evolution. Below -200 m, the ore veins are mainly Au mineralized, and Sb mineralization weakens. Based on the analogical analysis of metallogenic geological conditions, combined with favorable ore-hosting strata, fault structure systems, and geochemical anomalies, three favorable metallogenic target areas (Ⅰ, Ⅱ, and Ⅲ) are delineated. Some target areas have discovered gold orebodies through engineering verification, confirming the rationality of the prediction. This study clarifies the metallogenic mechanism and mineralization regularity of the deposit, provides theoretical support and target area guidance for the deep and peripheral resource exploration of the mining area, and has important practical significance for ensuring the resource replacement of the mine.