Abstract: The Xinfang gold deposit is a large gold deposit on the southern edge of the Liaodong Peninsula, China. It consists of five vein belts including 22, 23, 24, 25 and 27.The main ore bodies in the study area have been discovered, and energy enhancement and storage have become the factors restricting the continuous service of the mines. There is an urgent need for the deployment of drilling works in the process of ore deposit exploration to be based on scientific and effective mineralization prediction. This paper analyzes the geochemical characteristics of primary halo and zoning pattern of mineralization halo elements from 14 drillings within No.106 exploration line section in Xinfang gold deposit. Based on geochemical characteristics of primary halo, establish the axial zoning sequence and make prospecting prediction in the depth of the No.106 exploration line section. The study shows that the frontal elements are As, Sb, Hg, the near-ore indicator elements are Au, Ag, Cu, Pb, Zn and the rear elements are W, Mo, Bi in the Xinfang gold deposit. Axial zonation sequence of five lodes (including lode 22, 23, 24, 25 and 27) derived from the Grigorian’s zoning index method all present reverse zoning phenomenon, which are probably caused by multiple phases of mineralization. Stronger frontal halos and near-ore halos appear in the middle and lower part of lode 22, 23, 24 and 27, and the axial geochemical parameters of As/W, As/Mo, Sb/W, （As×Sb）/（Mo×W） have multiple oscilation fluctuations and increasing in the depth, which indicate better prospecting potential for those lodes in the depth. These features suggested that the ore bodies formed by multiple hydrothermal mineralization stages and some ore bodies may extend to the depth on the east side of No.106 exploration line section.