Abstract: On the basis of 1:50000 stream sediment survey, the authors made a preliminary analysis of the geochemical characteristics and main control factors of Zhusileng area in Inner Mongolia. The relationship of element distribution, element correlation analysis and single element anomaly to structure and the relationship between the anomaly and structure were investigated. It is found that Cu, Au, and Sb are potential prospecting elements in this area, which form a half-ring ore-forming and halo-forming center in relatively high accord with the fault structure in the converting Zhusilenghaierhan zone of inner and outer spiral surface at the south end of reverse "S" structure of Hulunxibai-Zhusilenghaierhan. Therefore, it is concluded that there may be hydrothermal copper polymetallic ore deposit related to the formation of intermediate-acidic intrusive rocks, where the gold deposit in Zhusilenghaierhan and two gold-antimony prospecting targets respectively in southern and northern Daobuqingwusu are strictly controlled by reverse "S" structure of Hulunxibai-Zhusilenghaierhan.